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Daam1 is a regulator of filopodia formation and phagocytic uptake of Borrelia burgdorferi by primary human macrophages.
Hoffmann AK, Naj X, Linder S. Hoffmann AK, et al. FASEB J. 2014 Jul;28(7):3075-89. doi: 10.1096/fj.13-247049. Epub 2014 Apr 2. FASEB J. 2014. PMID: 24696301
Using immunofluorescence, we localized endogenous and overexpressed Daam1 to filopodia and to F-actin-rich uptake structures. Live-cell imaging further showed that Daam1 is enriched at coiling pseudopods that arise from the macrophage surface. ...These data identify …
Using immunofluorescence, we localized endogenous and overexpressed Daam1 to filopodia and to F-actin-rich uptake structures. Live-ce …
First Evidence of DAAM1 Localization During the Post-Natal Development of Rat Testis and in Mammalian Sperm.
Pariante P, Dotolo R, Venditti M, Ferrara D, Donizetti A, Aniello F, Minucci S. Pariante P, et al. J Cell Physiol. 2016 Oct;231(10):2172-84. doi: 10.1002/jcp.25330. Epub 2016 Mar 6. J Cell Physiol. 2016. PMID: 26831620
We show that, in mitotic phases, DAAM1 shares its localization with actin in Sertoli cells, gonocytes, and spermatogonia. Later, during meiosis, both proteins are found in spermatocytes, while only actin is detectable at the forming blood-testis barrier. DAAM1 …
We show that, in mitotic phases, DAAM1 shares its localization with actin in Sertoli cells, gonocytes, and spermatogonia. Later, duri …
Human neuroglial cells internalize Borrelia burgdorferi by coiling phagocytosis mediated by Daam1.
Williams SK, Weiner ZP, Gilmore RD. Williams SK, et al. PLoS One. 2018 May 10;13(5):e0197413. doi: 10.1371/journal.pone.0197413. eCollection 2018. PLoS One. 2018. PMID: 29746581 Free PMC article.
Coiling of B. burgdorferi was significantly reduced when neuroglial cells were pretreated with anti-Daam1 antibody indicating the requirement for Daam1 for borrelial phagocytosis. ...Evidence for native Daam1 and BBA66 interaction was suggested by colocalizat …
Coiling of B. burgdorferi was significantly reduced when neuroglial cells were pretreated with anti-Daam1 antibody indicating the req …
Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets.
Higashi T, Ikeda T, Shirakawa R, Kondo H, Kawato M, Horiguchi M, Okuda T, Okawa K, Fukai S, Nureki O, Kita T, Horiuchi H. Higashi T, et al. J Biol Chem. 2008 Mar 28;283(13):8746-55. doi: 10.1074/jbc.M707839200. Epub 2008 Jan 24. J Biol Chem. 2008. PMID: 18218625 Free article.
The association between RhoA and Daam1 was induced by thrombin stimulation in platelets, and RhoA-bound endogenous formins induced actin assembly, which was inhibited by the DID domains of Daam1 and mDia1. Thus, mDia1 and Daam1 are platelet actin assembly fac …
The association between RhoA and Daam1 was induced by thrombin stimulation in platelets, and RhoA-bound endogenous formins induced ac …
Association Between Wnt Target Genes and Cortical Volumes in Alzheimer's Disease.
Dong L, Hou B, Liu C, Mao C, Huang X, Shang L, Chu S, Peng B, Cui L, Feng F, Gao J. Dong L, et al. J Mol Neurosci. 2023 Dec;73(11-12):1010-1016. doi: 10.1007/s12031-023-02122-1. Epub 2023 Dec 23. J Mol Neurosci. 2023. PMID: 38135866 Free PMC article.
Herein, we aim to illustrate the effect of the Wnt target genes on the cortical volumes of AD patients. 82 sporadic AD patients were recruited. All the subjects had history survey, blood biochemical examination, cognitive assessment, MRI morphometry and whole exome sequenc …
Herein, we aim to illustrate the effect of the Wnt target genes on the cortical volumes of AD patients. 82 sporadic AD patients were recruit …
Systematic analysis of microRNA fingerprints in thrombocythemic platelets using integrated platforms.
Xu X, Gnatenko DV, Ju J, Hitchcock IS, Martin DW, Zhu W, Bahou WF. Xu X, et al. Blood. 2012 Oct 25;120(17):3575-85. doi: 10.1182/blood-2012-02-411264. Epub 2012 Aug 6. Blood. 2012. PMID: 22869791 Free PMC article.
Integration of transcriptomic and mass spectrometric datasets with functional reporter assays identified dishevelled associated activator of morphogenesis 1 (DAAM1) as a miR 490 5p protein target demonstrating decreased expression in ET platelets, putatively by translation …
Integration of transcriptomic and mass spectrometric datasets with functional reporter assays identified dishevelled associated activator of …
Differentiation of tubular and villous adenomas based on Wnt pathway-related gene expression profiles.
Nguyen AV, Albers CG, Holcombe RF. Nguyen AV, et al. Int J Mol Med. 2010 Jul;26(1):121-5. doi: 10.3892/ijmm_00000443. Int J Mol Med. 2010. PMID: 20514431
Genes involved in non-canonical Wnt signaling with increased expression in villous adenomas included rho-u, daam1, damm2, cxxc4 and nlk. Successive increases in the expression of ctnnb1 (beta-catenin) from normal to tubular adenomas to villous adenomas was seen. ...
Genes involved in non-canonical Wnt signaling with increased expression in villous adenomas included rho-u, daam1, damm2, cxxc4 and n …
Monocyte-mediated regulation of genes by the amyloid and prion peptides in SH-SY5Y neuroblastoma cells.
Morte B, Martínez T, Zambrano A, Pascual A. Morte B, et al. Neurochem Int. 2011 May;58(6):613-9. doi: 10.1016/j.neuint.2011.01.019. Epub 2011 Feb 12. Neurochem Int. 2011. PMID: 21303680 Free article.
According to microarray analysis, not many coincidences are observed and only four genes (Hint3, Psph, Daam1 and c-Jun) appear to be commonly upregulated by both peptides. ...
According to microarray analysis, not many coincidences are observed and only four genes (Hint3, Psph, Daam1 and c-Jun) appear to be …
A vertebrate-specific Chp-PAK-PIX pathway maintains E-cadherin at adherens junctions during zebrafish epiboly.
Tay HG, Ng YW, Manser E. Tay HG, et al. PLoS One. 2010 Apr 12;5(4):e10125. doi: 10.1371/journal.pone.0010125. PLoS One. 2010. PMID: 20405038 Free PMC article.
Regulatory mechanisms involving directed E-cadh trafficking have been invoked downstream of Wnt11/5 signaling. This non-canonical Wnt pathway regulates RhoA-ROK/DAAM1 to control the acto-myosin network. However, in this context nothing is known of the intracellular signals …
Regulatory mechanisms involving directed E-cadh trafficking have been invoked downstream of Wnt11/5 signaling. This non-canonical Wnt pathwa …
ERG transcriptional networks in primary acute leukemia cells implicate a role for ERG in deregulated kinase signaling.
Bock J, Mochmann LH, Schlee C, Farhadi-Sartangi N, Göllner S, Müller-Tidow C, Baldus CD. Bock J, et al. PLoS One. 2013;8(1):e52872. doi: 10.1371/journal.pone.0052872. Epub 2013 Jan 3. PLoS One. 2013. PMID: 23300998 Free PMC article.
Our findings of chromatin immunoprecipitation-on-chip of primary samples revealed 48 significantly enriched single genes including DAAM1 and NUMB. Significantly enriched signaling pathways included WNT/beta-catenin, p53, and PI3K/AKT with ERG overexpression inducing dephos …
Our findings of chromatin immunoprecipitation-on-chip of primary samples revealed 48 significantly enriched single genes including DAAM1 …
12 results